Fresh analysis suggests that people who come off blockbuster weight-loss injections like semaglutide or tirzepatide can put back on lost weight at a significantly accelerated pace than those who halt conventional diet and exercise programs.
Published data in a major medical journal shows that while obese individuals often shed a large proportion of their total mass while using the jabs, the mass comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"People using these medications must be informed of the risk of rapid weight regain when the treatment ends," cautioned researcher Dr. Susan Jebb.
That rate of regain means a reversion to pre-treatment weight in about one and a half years.
Weighing Approaches
The research, which examined dozens of studies involving over 9,000 of participants, contrasted the results of these new drugs with conventional dieting.
The team note that individuals who shed pounds through dieting typically experience a less rapid weight regain—approximately 0.1 kg a month—post-intervention.
Understanding the Rapid Regain
Nutrition scientists believe the mechanism of the injections accounts for the heightened regain.
These medications mimic a body's own chemical called GLP-1, which controls hunger.
"Sustained high doses of GLP-1 concentrations far above than normal could lead to the body to produce less of its own natural hormone, and could lessen responsiveness to its effects," said Dr. Adam Collins, a nutrition expert.
"Withdrawal of this hormone supplement results in appetite is no longer kept in check, making binge eating far more likely."
An Ongoing Disease?
The NHS advise the injections for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Professionals contend that, considering the high risk of weight regain, the therapy should be considered ongoing.
This view is supported by pharmaceutical companies, who say that the results "highlight the persistent character of excess weight," similar to managing conditions like high blood pressure.
Patient Accounts
Individuals who have discontinued the medication explain a sudden resurgence of appetite.
"It felt as if a switch that goes on and I was suddenly starving," described a patient.
This challenge is exacerbated if patients have not developed lasting dietary or behavioural changes during therapy.
Significant Interest
Survey data indicate that a significant number of adults in the UK have used weight-loss jabs in the past year, with desire remaining high.
- Use is more common among women compared to males.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Finally, clinicians emphasize that while these medications are powerful tools for shedding pounds, they are not a magic solution and lasting health benefits hinges on ongoing behavioural changes.
